HOIST Co.,Ltd.

At the AACR ANNUAL MEETING to be held in San Diego, U.S. from April 5, we will present a progress report on the
drug development (HOIST Project No. HM-001) utilizing the MA-T system for the treatment of non-invasive bladder
cancer (NMIBC) in the muscle layer. Here, we will add the results of drug efficacy evaluation utilizing the PDX
(Patient-Derived Cancer Transplantation Model) and present data (poster presentation) on the expected efficacy in
low- and intermediate-risk patients, which is a large patient population among NMIBC. This evaluation system is only
available at HOIST worldwide.

AACR Annual Meeting 2024